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A model additionally adjusting for average cigarette pack price (Supplementary Analysis 2) produced very similar resultsbut slightly reduced, as adjusting for cigarette pack priceone mechanism of substitutionwould be expected to diminish the overall aggregate substitution effect

And so when you have a closed system, you essentially just end up accumulating a lot of those metals over time, and you end up with higher concentrations in the aerosol that people breathe, he tells Rolling Stone